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Natural hormone molds leaner bodies in mice

first_imgA natural hormone that is increased by physical exercise and by exposure to cold improves blood sugar control, suppresses inflammation, and burns fat to mold leaner bodies in mice, report scientists at Dana-Farber Cancer Institute, a principal teaching affiliate of Harvard Medical School.The hormone, called meteorin-like protein, or Metrnl, can be made in the laboratory. Its health-promoting properties make it a promising candidate for treating obesity and other metabolic diseases, inflammation, and possibly other disorders, said principal investigator Bruce Spiegelman of Dana-Farber’s Cancer Biology department.“This might have interesting therapeutic potential for several diseases,” said Spiegelman, the Stanley J. Korsmeyer Professor of Cell Biology and Medicine at Harvard Medical School. “Because it targets the immune cells involved in tissue repair it will also be interesting to see if this protein affects muscle repair in certain neuromuscular diseases.”Reporting in Cell, the researchers said that extra Metrnl injected into mice achieved some of the same effects as exercise. It decreased their body fat by 25 percent and caused them to lose weight even on a high-fat diet. It improved their blood sugar control, stimulated conversion of chemical energy to heat, and turned on anti-inflammatory genes.The meteorin-like protein had previously been identified, but the new study is the first to reveal its role as a hormone — a biological messenger in blood — involved in metabolism and energy balance, according to the researchers. The study adds Metrnl to an emerging picture of why exercise has many healthful benefits, from weight loss to suppressing inflammation to combating metabolic diseases.In addition, Metrnl has an important role in dialing up fat-burning to maintain core heat production in mice exposed to cold temperatures, the study revealed. The researchers said this indicates that Metrnl is part of the body’s mechanism for adapting to environmental changes.Unlike other exercise-related proteins that stimulate “thermogenesis” — burning calories to create heat — Metrnl works mainly through the immune system, rather than directly on fat cells, said Spiegelman. The scientists found that Metrnl activates an alternative molecular pathway by which immune cells are recruited to enter fatty tissue, where they trigger the fat-burning process.“The idea of a protein acting primarily through the immune cells in the fat is pretty amazing, at least in our view,” Spiegelman said.The Metrnl findings come two years after the Spiegelman group isolated a different protein, irisin, produced in muscles by endurance as opposed to resistance exercise, which stimulates Metrnl secretion. Irisin also promotes the browning of fat to release energy and causes mice to lose weight; like Metrnl, irisin improves glucose tolerance, which helps prevent diabetes.From the viewpoint of developing therapies, “It is a good thing to have molecules that work through different pathways,” said Spiegelman. Irisin is being studied as a potential treatment for obesity and type 2 diabetes and has been licensed commercially.The first author of the report is Rajesh R. Rao of Dana-Farber. Other authors are from Dana-Farber, Harvard Medical School, The Karolinska Institutet of Sweden, Australian Catholic University, Liverpool John Moores University, and Ember Therapeutics.The research was funded by a grant from the National Institutes of Health.last_img read more

Rohit Sharma and Umesh in Focus as BP XI Play SA in a Tour Game

first_imgVizianagaram (Andhra Pradesh): Rohit Sharma, who has been India’s regular opener in the shorter formats of the game, will have his first stint at the top of the order in red-ball cricket when he leads Board President’s (BP) XI against South Africa in the lone three-day tour game beginning on Thursday.Rohit, who has been one of India’s premier batsmen in the limited-overs set-up, has been given the opportunity to cement his place in the Test side and become a permanent feature in all the three formats by moving him to the top of the order.The 32-year-old will be challenged by Kagiso Rabada and company and will have a good taste of what he would be up against in the three-Test series which begins on October 2 in Visakhapatnam.The tour game will also prove to be a good opportunity for Umesh Yadav who has been inducted into the squad as a replacement for the injured Jasprit Bumrah. Bumrah has suffered a minor stress fracture in his lower back and was ruled out on Tuesday.The game will be a good dress rehearsal before the Visakhapatnam Test as the likes of Ajinkya Rahane and Hanuma Vihari, who were among the runs against the lackluster bowling line-up of the West Indies, will be facing the quality red ball attack of South Africa, comprising Rabada, Vernon Philander and Lungi Ngidi.Another player who will be in focus is Karun Nair along with Umesh Yadav — India’s second triple centurion after Virender Sehwag. Nair had a poor domestic season last year and even though he was in England for the Test series, he didn’t get a game. Nair will be aiming to score some big runs in order to force the selectors to find a way for him in the squad.Meanwhile, for the Proteas, regular skipper Faf du Plessis is back with the team and he would be raring to come out and make a statement after he was ignored for the T20I series as Cricket South Africa has decided to try Quinton de Kock in the shorter format.Squads: Board President’s XI: Rohit Sharma (captain), Mayank Agarwal, Priyank Panchal, AR Easwaran, Karun Nair, Siddhesh Lad, KS Bharat (wicket-keeper), Jalaj Saxena, Dharmendrasinh Jadeja, Avesh Khan, Ishan Porel, Shardul Thakur, Umesh Yadav.South Africa: Faf du Plessis (captain), Temba Bavuma (vc), Theunis de Bruyn, Quinton de Kock, Dean Elgar, Zubayr Hamza, Keshav Maharaj, Aiden Markram, Senuran Muthusamy, Lungi Ngidi, Anrich Nortje, Vernon Philander, Dane Piedt, Kagiso Rabada, Rudi Second. (IANS)Also Read: Bumrah Should be Played in Home Test: Indian Pacer Chetan SharmaAlso Watch:PHED takes out awareness rally against plastic in Hojai | The Sentinel News | Assam Newslast_img read more

Calvinaugh Jones finds stability at D-II Concord after numerous housing relocations

first_img Facebook Twitter Google+ Published on September 24, 2015 at 9:14 pm Contact Sam: [email protected] | @Sam4TR Calvinaugh Jones stepped out of the car he’d been in for 16 hours and dropped his duffel full of clothes onto the curb.He and his brother-in-law, Eric Jackson, had left West Virginia at 2 a.m. and driven to Dallas, Jones’ new home for the next 12 weeks.Jones shook hands with Clode Tatum, Jackson’s old army buddy, and walked into the house. Jones swapped chores and paid rent for the opportunity to train alongside established NFL running backs at the Michael Johnson Performance Center in McKinney, Texas.Jones, a senior at Division II Concord University in Athens, West Virginia, is coming off a first-team All-American season in 2014 when he rushed for 1,734 yards. At the end of the season, he decided to move from Maryland to Texas in hopes of becoming better, maybe NFL material, and he took the lessons from his childhood with him. This season, Jones has 208 all-purpose yards in three games. Jones never lived in one place longer than two years, which made finding friends difficult but focusing on football easier. While Texas felt foreign, the journey was familiar.“When he got out of school when he was younger, we just packed up and moved,” his mother Regina Jones said. “I was like a gypsy mom.”AdvertisementThis is placeholder textJones moved 12 times before high school, mostly within Wisconsin and Minnesota. As a seventh grader in Minnesota, Jones ran well in a rec league and coaches from a local powerhouse high school program noticed. Jones imagined success there, but was disappointed when the family moved again.His father, Calvin Jones, inherited a house in Macon, Georgia after Calvinaugh’s grandmother died. The Jones’ arrived too late for Calvinaugh to start football. When the family miscalculated how much the house would cost, they sold it and moved again. He began his high school career in Maryland and became an all-conference running back.“I keep moving, but football is my constant,” Jones said.Jones escaped loneliness in Texas through football. He trained five days per week, usually 9:30 a.m. to 4 p.m., working on upper body two days, lower body two days and taking a lighter day with yoga. He played in seven-on-sevens late Monday nights with Ronnie Braxton, who also trains NFL Pro Bowlers.He had one friend from Concord he saw occasionally. He learned independence and that people would come in and out of his life when he moved so much, he said. In seventh grade, when a friend started smoking marijuana, Jones disassociated himself, Calvin Jones said, because he didn’t want to hurt his chances with football.“I have good friends, but I wouldn’t say I made lifelong friends because of the moving,” Jones said. “It helped me a little (not to be close with anyone) because I just focused on football.”Jones didn’t know many people in Texas, but he knew the men ahead of him in running back drills at the performance center. Jones watched how NFL players like Darren McFadden, Jerry Hughes and Knile Davis trained. How Ameer Abdullah pumped his arms even while running slow and how he kept his feet shoulder-width for balance and quick cuts. Jones, who wanted to improve his pass-catching, took note of how quickly the NFL guys turned their heads after completing a route.Jones was the only collegiate player to line up for reps with pros, his trainer Drew Cuffee said. Players from Baylor and Football Championship Series schools also trained there. Cuffee praised Jones’ receptiveness and consistency. Jones didn’t miss one work out all summer.When Jackson returned to Texas, he noticed defined biceps, thicker legs and bulkier shoulders. Jones’ body fat slimmed from 12 percent to seven.Jones knows the NFL is a longshot, especially for a Division II athlete. However, Cuffee, a former Division II defensive back at Abilene Christian, had five teammates make the NFL, one of whom started 128 games in an eight-year career.“I can see the difference between NFL talent and not NFL talent,” Cuffee said. “(Jones) has the potential to get there. He’s put himself in a position.”This spring, Jones will try to turn pro, but his success is far from guaranteed.Only one thing is for sure. If a professional chance presents itself, no matter where it is, he’ll take it.He won’t mind moving. Commentslast_img read more